While the coronavirus disease‐2019 (COVID‐19) might have increased acute episodes in people living with sickle cell disease (SCD), it may also have changed their reliance on emergency department (ED) services. We assessed the impact of the COVID‐19 pandemic and lockdowns on ED visits in adult SCD people followed in five French reference centres, with a special focus on ‘high users’ (≥10 visits in 2019). We analysed the rate of ED visits from 1 January 2015 to 31 December 2021, using a self‐controlled case series. Among 1530 people (17 829 ED visits), we observed a significant reduction in ED visits during and after lockdowns, but the effect vanished over time. Compared to pre‐pandemic, incidence rate ratios for ED visits were 0.59 [95% CI 0.52–0.67] for the first lockdown, 0.66 [95% CI 0.58–0.75] for the second and 0.85 [95% CI 0.73–0.99] for the third. High users (4% of people but 33.7% of visits) mainly drove the reductions after the first lockdown. COVID‐19 lockdowns were associated with reduced ED visits. While most people returned to their baseline utilization by April 2021, high users had a lasting decrease in ED visits. Understanding the factors driving the drop in ED utilization among high users might inform clinical practice and health policy.