The aim of this paper is to see how science fiction can be used in the ESP classroom with Science and Technology students. Following on from previous work in this field, this paper explores how we can make space for science fiction in ESP teaching, and on what grounds. We first show how passages from science fiction novels such as Margaret Atwood’s Oryx and Crake, films like Interstellar and video games like Half-Life can be used effectively with students specialising in biotechnology or astrophysics. Our aim is to both analyse the scientific content of these works of fiction and appreciate the educational dimension of the genre and what it can bring to S&T students, in terms of both science and ethical questioning. We start with a brief historical overview of science fiction as a popular genre, its beginnings, and its role with regard to science popularisation. We then proceed to analyse its pedagogical potential and present specific examples of the possibilities these works offer in the context of ESP classes for science and technology students.